Effects of SRC and IKKβ Kinase Inhibition in Ischemic Factors Modeling In Vitro and In Vivo

The search for new molecular targets whose modulation can reduce nerve cell dysfunction and neuronal death during ischemic damage is one of the most significant issues in both fundamental clinical neurobiology. Various kinase enzymes are often considered to be such promising since they involved key cascades that regulate adaptation stress factors. Our work devoted study role two kinases—SRC IKKβ—in maintaining neural networks’ functional activity under a hypoxic condition vivo vitro. SRC cytoplasmic non-receptor protein tyrosine kinase. It regulation proliferation differentiation; its expression cells changes hypoxia. IKKβ transcription factor NF-κB, which pleiotropic regulator many cellular signaling pathways. We have shown blockade kinases by selective inhibitors maintains viability modeling vitro but does not allow preservation bioelectrical neurons. Studies neuroprotective effect inhibition cerebral ischemia mice.